The Berger Group at UC Berkeley
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Costa A, Ilves I, Tamberg N, Petojevic T, Nogales E, Botchan MR, Berger JM. Nat Struct Mol Biol, 18(4):471-7, 2011.
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.
Schmidt BH, Burgin AB, Deweese JE, Osheroff N, Berger JM. Nature. 2010, 465:641-4
Origin remodeling and opening in bacteria relies on distinct assembly states of the DnaA initiator.
Duderstadt KE, Mott ML, Crisona NJ, Chuang K, Yang H, Berger JM. J Biol Chem. 285:28229-39, 2010.
Structural and mechanistic biochemistry of protein/nucleic acid machines and assemblies
A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs. Tretter EM, Lerman JC, Berger JM. Proc Natl Acad Sci USA, 107:22055-9, 2010.
Running in reverse: the structural basis for translocation polarity in hexameric helicases. Thomsen ND, Berger JM. Cell. 2009, 139:523-34.
Mott ML, Erzberger JP, Coons MM, Berger JM. Cell. 2008, 35:623-34.
Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex. Dueber EL, Corn JE, Bell SD, Berger JM. Science. 2007, 317:1210-3.
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We are part of the Dept. of Molecular and Cell Biology and the QB3 Institute on the Berkeley campus, and the Physical Biosciences Division at Lawrence Berkeley Lab:
