The Berger Group at UC Berkeley


The structural basis for MCM2-7 helicase activation by GINS and Cdc45.  Costa A, Ilves I, Tamberg N, Petojevic T, Nogales E, Botchan MR, Berger JM. Nat Struct Mol Biol, 18(4):471-7, 2011.

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.

Schmidt BH, Burgin AB, Deweese JE, Osheroff N, Berger JM. Nature. 2010, 465:641-4

Origin remodeling and opening in bacteria relies on distinct assembly states of the DnaA initiator.

Duderstadt KE, Mott ML, Crisona NJ, Chuang K, Yang H, Berger JM. J Biol Chem. 285:28229-39, 2010.


Structural and mechanistic biochemistry of protein/nucleic acid machines and assemblies

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Information for those interested in our research:

Post-doctoral positions

Prospective graduate students



We are part of the Dept. of Molecular and Cell Biology and the QB3 Institute on the Berkeley campus, and the Physical Biosciences Division at Lawrence Berkeley Lab:

UC Berkeley ➔   MCB ➔

QB3 ➔    BSMB

LBNL ➔   MacroLab ➔